1
15
4
-
https://d1y502jg6fpugt.cloudfront.net/17269/archive/files/92e83cb3827f853cdf24b523580f7f99.pdf?Expires=1712793600&Signature=wENR4Jn%7Er5f3ysJ9gAZSjKlOhZ3rNCSCenbeAOgfBh%7Ev8ICj3i-5YC%7EugpT%7EaEXCsWC-mEYqT9TIesw9crCB6MFsZrYRZEFq-NwpyyWG9Fk7fPpDqj2E-tInJsRjk5bDMCJep1aOgMpDrxP%7Edu4L5Acn9MkouZz4CFBomw%7Ebx%7E8vqD8ObHv3dfljqREoqkjc0MLQ11-uflKNT3QL-emVVjeGDFrSXQ1D8MigvwJJVkUqJ9LjOfZyVSeLclcjR8K-KRrDNe13dJuiyr-O3QG7BeHr8WIAHJdwDEwgNYZ9WAVcL5hYBbwHF30Eip%7EzBgxDvTH38PIvglrBeyj9GUhEeg__&Key-Pair-Id=K6UGZS9ZTDSZM
bc5d085acdf07604b1f2c4add3b5cf16
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Senior Showcase 2016
Description
An account of the resource
Oral and poster presentations from Senior Showcase held on April 19, 2016 at Ripon College.
Publisher
An entity responsible for making the resource available
Ripon College Lane Library
Date
A point or period of time associated with an event in the lifecycle of the resource
April 2016
Contributor
An entity responsible for making contributions to the resource
Ripon College Seniors 2016
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Toward the Structure of the C-terminal Domain of EcoR124I Restriction Enzyme by Nicholas Leudtke
Subject
The topic of the resource
Chemistry
Creator
An entity primarily responsible for making the resource
Luedtke, Nicholas
Grinkevich, Pavel
McIntosh, Bennett
Baikova, Tatsiana
Lapkouski, Mikalai
Ettrich, Rüdiger
Carey, Jannette
Source
A related resource from which the described resource is derived
Senior Showcase Poster presentation
Publisher
An entity responsible for making the resource available
Ripon College
Date
A point or period of time associated with an event in the lifecycle of the resource
April 19, 2016
Rights
Information about rights held in and over the resource
The author reserves all rights.
Identifier
An unambiguous reference to the resource within a given context
Major: Chemistry
Appleton, WI
Description
An account of the resource
Using the type I restriction-modification (R-M) system of plasmid EcoR124I, E. coli cells systematically distinguish their own DNA from foreign DNA. Self DNA is protected by
methylation within a specific recognition sequence, while foreign DNA, which lacks methylation, promotes DNA translocation through the stationary R-M enzyme and cleavage at unspecific sites. The R-M system consists of three subunits: HsdS (specificity), HsdM (modification) and HsdR (restriction).
The published structure of the HsdR subunit of EcoR124I1 contained four functionally integrated domains. The last 150 amino acids in the C-terminal domain were unresolved in the crystal structure. A single point mutation led to a new crystal structure indicating that the last 150 residues form a 5th domain perpendicular to the other four domains.
To facilitate expression and crystallization, the C-terminal part of HsdR was appended after a fluorescent protein domain and a hexahistidine tag. Three constructs that include HsdR residues 705-1038, 867-1038, or 887-1038 were developed through PCR mediated deletions. Following expression, each protein was purified by nickel-NTA affinity and DEAE-Sepharose anion exchange chromatography. Crystals of the construct containing residues 887-1038 diffract x-rays to 8 Å and a model structure has been predicted for the C-terminal domain.
Molecular dynamics simulations with GROMACS software is being used to simulate the restriction subunit. The aim is to estimate if the proposed C-terminal structure maintains its secondary and tertiary structures during molecular dynamics simulations in solvent. Simulations of the protein are being examined for features that can evaluate the acceptability of the current model of EcoR124I.
This project was completed with all of the creators listed below, as well as the support from the Czech Science Foundation (P207/12/2323) and the United States National Science Foundation REU program (award 1358737).
Chemistry
Crstallography
Crystallization
EcoR124I
Enzyme
molecular dynamics
Protein
Restriction-Modification
structure
X-Ray diffraction
-
https://d1y502jg6fpugt.cloudfront.net/17269/archive/files/49f73869397e6aa93762d6ddd74124f5.pdf?Expires=1712793600&Signature=ishZROWN0VpPuwemOTMfs7DZig8DCw4W%7E8h5daCTfKGwtEZW%7Edj7ZJ%7ERKG4vieqvqryI2g5KcDJsDLsh%7E2l9WJzTaS7TIGUPDXmPszVSTBHo4469mHpxqWcZwfB8KQ7PpjV8g6454L6mgYWtAVWE3YZ6tVVo2h7mjqAniEw5-Wn5TIpXg3GzVY7IRuGwp0GK8BMo9-N4mrRz9WIwFDYxmR0mTC040OBpZY7Mq62Yjvy1c%7EmNLkihsEjCz8KUU4O7q8RwPK8o0NaBYjLJ6HII-qDUDafAU5lm6EO%7EKdxRyUQptjtGKV4JZb-vhp5uCJpLhSexyPUkd-ZhFxy2bWdy-A__&Key-Pair-Id=K6UGZS9ZTDSZM
4a62c5aedd89ec85092c8b5eb8bf8c7c
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Senior Showcase 2015
Description
An account of the resource
Oral and poster presentations from Senior Showcase held on April 23, 2015 at Ripon College.
Creator
An entity primarily responsible for making the resource
Ripon College
Publisher
An entity responsible for making the resource available
Ripon College Lane Library
Date
A point or period of time associated with an event in the lifecycle of the resource
April 23, 2015
Contributor
An entity responsible for making contributions to the resource
Scholars Week
Format
The file format, physical medium, or dimensions of the resource
pdf
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Lithium-Promoted Reaction of Aldehydes with N-Acylphthalimides by Lucas Henningsen
Subject
The topic of the resource
Chemistry
Creator
An entity primarily responsible for making the resource
Henningsen, Lucas
Source
A related resource from which the described resource is derived
Senior Showcase Poster presentation
Publisher
An entity responsible for making the resource available
Ripon College
Date
A point or period of time associated with an event in the lifecycle of the resource
April 23, 2015
Rights
Information about rights held in and over the resource
The author reserves all rights.
Format
The file format, physical medium, or dimensions of the resource
pdf
Identifier
An unambiguous reference to the resource within a given context
Major: Chemistry-Biology
Minor: Music
Rice Lake, Wisconsin
Description
An account of the resource
Phthalimides can easily be converted into primary amines, which are useful in a wide variety of laboratory and industrial applications. A new reaction has been discovered which allows for the synthesis of N-phthalimido-O-acyl-N,O-acetals from acyl phthalimides and aldehydes. These products can undergo hydrazinolysis to become useful primary amines. In addition, it is possible to combine the reaction with the synthesis of the participating acyl phthalimides, resulting in a one-pot synthesis of N-phthalimido-O-acyl-N,O-acetals from an acid chloride, phthalimide salt, and aldehyde.
Previous research showed that a metal Lewis acid and a tertiary amine were required for the reaction to take place. The optimal conditions included at least 10 mole percent LiBF4 and acetonitrile as the solvent. The reaction proceeds to 99% completion in less than 1 hour. Early mechanistic experiments show that the acyl group and phthalimide group completely dissociate to facilitate the insertion of the aldehyde.
Aromatic Chemistry
Chemical Synthesis
Chemistry
Methodology
New Reactions
Organic Chemistry
-
https://d1y502jg6fpugt.cloudfront.net/17269/archive/files/b91d24b41bf831993e56141bf2a6f045.pdf?Expires=1712793600&Signature=BcEhnReqBVZV4ExY514B8R1cnlOdT1NW7uGrfB%7EXsr2Qws7lQKJLIxkU8mW-axtnCIUudOX1DdJ9ZEYKilKpz3bAIl1rvC%7EOukhvdDhTYAn84PjPAJIyPXi%7EeaIQc5kMrsnuCDCEwjT099cbRrP2U9VDe%7Eqte0QqzeIIic1akt4jY5KhfbXDtTzjp54-d7cOQ1H1hNAwAXOTg4jMgIKi2MgwttOL1xFWj6GCnxQg0iEqIRMS01kaiV9zPjnAJZmp6MlUhYvVciq-p-WHZUk82oxo85A4xYN4qB4miQecGB6TryTzAylDM6L6mQ8D9KPJD8bQsuQixecYcx9KiGpW-Q__&Key-Pair-Id=K6UGZS9ZTDSZM
d9614ac2cbeae3a14ed1689ddc4f44c3
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Senior Showcase 2015
Description
An account of the resource
Oral and poster presentations from Senior Showcase held on April 23, 2015 at Ripon College.
Creator
An entity primarily responsible for making the resource
Ripon College
Publisher
An entity responsible for making the resource available
Ripon College Lane Library
Date
A point or period of time associated with an event in the lifecycle of the resource
April 23, 2015
Contributor
An entity responsible for making contributions to the resource
Scholars Week
Format
The file format, physical medium, or dimensions of the resource
pdf
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Substituent and Solvent Effects: Examining Acidity via Infrared Spectroscopy by Jordan Buhle
Subject
The topic of the resource
Chemistry
Creator
An entity primarily responsible for making the resource
Buhle, Jordan
Source
A related resource from which the described resource is derived
Senior Showcase Oral presentation
Publisher
An entity responsible for making the resource available
Ripon College
Date
A point or period of time associated with an event in the lifecycle of the resource
April 23, 2015
Rights
Information about rights held in and over the resource
The author reserves all rights.
Format
The file format, physical medium, or dimensions of the resource
pdf
Identifier
An unambiguous reference to the resource within a given context
Major: Chemistry
Minors: Spanish, Physics
Milton, Wisconsin
CHM 502 Chemistry Senior Seminar
Description
An account of the resource
There is a large collection of substituent constant data measured in polar protic and polar aprotic solvents, but a lack of information on substituent effects in nonpolar aprotic solvents. In this study, substituent effects on the acidities of phenol derivatives were examined in CCl4 using infrared (IR) spectroscopy. The IR peak of the free phenolic -OH appears at approximately 3600 cm-1 which is red shifted in the presence of a hydrogen bond acceptor. The magnitude of the splitting between the free and the hydrogen-bonded -OH peak is related to the acidity of the protic hydrogen. Deuterated acetonitrile was used as the hydrogen-bond acceptor to probe the relative acidities of 21 phenol derivatives in CCl4. While most phenol derivatives exhibited similar acidity trends in CCl4 as in DMSO and the gas phase, several demonstrated a reduction in acidity which indicates a solvent dependence on substituent effects. This study offers a facile method to examine substituent effects on the acidity of alcohols and has identified several solvent-dependent substituent effects.
Acidity
Chemistry
IR spectroscopy
Solvent
Substituents
-
https://d1y502jg6fpugt.cloudfront.net/17269/archive/files/1fe3586dc01877bca1692839f683ce85.pdf?Expires=1712793600&Signature=hIevCB7hNdedyet3FiSxzcbsWpH0UWW6bgFiQNWmraHUgRsJVtfNFty3JTnfZUzX7Fia%7Ew5OPQsZOFIfv%7Efgc4ab6znntRwcnnxCStMpZMJ0S2Uuxl3S5zGoXK4W2itPbdfUQ-EVZMcb4yo4APDEbbbRRVWJySF9qyVda8upqMdlTNfxOSWPNRQOu82NV8yQh2bS2i8%7E2hjE1bhiFvhAQHBvfrr1tehuxsGfkGYf-Dz%7EDeui4V9oQk2ChX4435bv4PpvZPApDZmwYFNIveCdTnYUARU1sESt7aWM%7EBjPPYCgvVnXusK4Z-0SngxlmgDLdm-kP-cbZmHLr%7E1jJ07eFw__&Key-Pair-Id=K6UGZS9ZTDSZM
3e2b1a0a5b617c812e2f7f78388f79cc
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Senior Showcase 2015
Description
An account of the resource
Oral and poster presentations from Senior Showcase held on April 23, 2015 at Ripon College.
Creator
An entity primarily responsible for making the resource
Ripon College
Publisher
An entity responsible for making the resource available
Ripon College Lane Library
Date
A point or period of time associated with an event in the lifecycle of the resource
April 23, 2015
Contributor
An entity responsible for making contributions to the resource
Scholars Week
Format
The file format, physical medium, or dimensions of the resource
pdf
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sustainable Polymers Derived from Carbohydrates by Derek Saxon
Subject
The topic of the resource
Chemistry
Description
An account of the resource
Plastic waste is generated across the globe on an alarming scale, with only a small
fraction recovered for recycling. As a result, sustainable polymers derived from renewable
resources have recently been gaining attention. Carbohydrates offer an inexpensive, renewable
resource for the development of polymeric materials. The current study details the synthesis of
renewable aliphatic polyesters from two cyclic esters derived from glucose, gluconolactone (GL)
and acetyl-gluconolactone (AGL). Poly(gluconolactone) [PGL] and poly(acetyl-gluconolactone)
[PAGL] were prepared by ring-opening polymerization (ROP) at low temperatures and initiated
by an aluminum alkoxide with 1.0 mol% loading. Characterization was carried out via 1H NMR,
13C NMR, FT-IR, GC/EI-MS and LC/ESI-TOF MS. Analysis revealed the synthesis of highly
functional aliphatic polyesters with attractive properties. Density functional calculations were
performed with Gaussian 09 using the M06L functional and the 6-31G(d) basis set, suggesting a
metal-mediated coordination-insertion mechanism. These polymers are excellent candidates for
the manufacture of sustainable polymers derived from a fully renewable carbohydrate feedstock.
Creator
An entity primarily responsible for making the resource
Saxon, Derek
Source
A related resource from which the described resource is derived
Senior Showcase Oral presentation
Publisher
An entity responsible for making the resource available
Ripon College
Date
A point or period of time associated with an event in the lifecycle of the resource
April 23, 2015
Rights
Information about rights held in and over the resource
The author reserves all rights.
Format
The file format, physical medium, or dimensions of the resource
pdf
Identifier
An unambiguous reference to the resource within a given context
Major: Chemistry
Iron Mountain, Michigan
Carbohydrate
Chemistry
Polymer
Renewable
Ring-Opening Polymerization